Table 1. Group characteristics and immunological results of the 96 subjects enrolled in the cross-sectional study.
N | ART | Previous TB self-reported | PPD responders | PPD+ CD27 Ratio <1 | Median CD27 Ratio | Diagnostic Concordance MTB Culture* | |
TB−/HIV− | 32 | NA | 1 | 19 (59%) | 4 | 1.42 | 79% |
TB+/HIV− | 10 | NA | 0 | 8 (80%) | 8 | 0.48 | 80% |
TB−/HIV+ | 35 | 25 | 9 | 14 (40%) | 9 | 0.92 | 75% |
TB+/HIV+ | 18 | 0 | 0 | 16 (89%) | 14 | 0.27 | 78% |
NA = not applicable; ART = antiretroviral treatment; PPD+ CD27 Ratio = number of PPD-specific CD4 T cells positive for IFN gamma divided by the number of respective CD27− CD4 T cells.
*Diagnostic concordance MTB culture defines the proportion of concordant results defined by PPD response and CD27 expression of PPD-specific CD4 T cells.