Figure 1. Bortezomib promoted ATRA-induced growth arrest in human neuroblastoma CHP126 and SH-SY5Y cells.

SH-SY5Y and CHP126 cells were seeded and treated with bortezomib (A) or ATRA (B) for 96 h, and Trypan blue staining was used to detect the surviving cells. Dose-response curves of the two cell lines treated with bortezomib (A) and ATRA (B) are presented. SH-SY5Y (C) and CHP126 (D) cells were treated as described above. The cell growth curves were created by counting cells each day. Massive cell death of SH-SY5Y and CHP126 cells was induced by treatments (E and F). Data are shown as the means ± SE (n = 3).BTZ  =  bortezomib.