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| Groups | Dose(mg/kg) | Fluoresce indensity (a.u.) | Inhibition Rate (%) |
| control | -- | 56.2±22.5 | -- |
| ATRA | 5.0 | 29.1±24.4 | 47.1 |
| bortezomib | 0.5 | 31.8±25.3 | 43.4 |
| ATRA+ bortezomib | 5.0+0.5 | 8.6±7.1** | 84.7 |
**: P<0.001,vs ATRA.
