Table 5. Cumulative effect of risk factors of smoking, ADIPOQ rs1063538, BMI and ADIPOR1 rs1539355 in colorectal cancer susceptibility in combined study.
No. of risk factors | No. (cases/controls) | OR (95%CI)a | P | P for trend |
0 | 123/197 | 1.00 | <0.0001 | |
1 | 221/299 | 1.18(0.89–1.58) | 0.25 | |
2 | 203/175 | 1.87(1.38–2.54) | 5.38×10−5 | |
≥3 | 86/32 | 4.39(2.75–7.01) | 5.48×10−10 |
Adjusted by age, sex.