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. 2011 Nov 7;6(11):e27408. doi: 10.1371/journal.pone.0027408

Figure 2. Drosophila homologue of Ku70 (DmKu70) has a protective effect in vivo against the toxicity of mutant Htt.

Figure 2

(A) Axial sections of the Control Canton-S, GMR-Gal4/+;UAS-Htt103Q/+ and GMR-Gal4/+;gDmKu70/UAS-Htt103Q fly eyes are shown. The vacuolar degeneration was severer than that in Figure 2. In triple transgenic flies generated by mating GMR-Gal4/UAS-Htt103Q flies with UAS-mouse Ku70 flies, Ku70 co-expression partially recovered degeneration. Scale bar, 50 µm. (B) Quantitative analysis of the eye thickness of each transgenic fly. The numbers above each bar indicate the number of counted flies. Mean +/− SE. *: p<0.01, Student's t-test. All flies tested were female. Number of flies used for the experiments are indicated on the shoulder of each bar. The genetic background was w(CS10) in this figure.