Table 1. Selected CISs found in MMTV-induced mammary tumors.
| RTCGD Database | ||||||||
| Gene | Insertion | IS dist. * | Expression ** | BALB + | C3H + | Virus | Type | HBC # |
| Wnt pathway | ||||||||
| Antxr1/Tem8 | intron (1) | 26, 108 | + | 1 | 1 | LBC, IBC | ||
| Eda2r | −6 | - | 0 | 1 | IBC | |||
| Epha6 | intron | 23 | - | 0 | 1 | |||
| Foxl1 | −71 | + | 1 | 0 | MMTV | Mammary | ILC, DC | |
| Hhip | intron | 0.8 | - | 0 | 1 | |||
| Jag1 | intron | 11 | ++ | 0 | 1 | |||
| Lrp5 | intron | 39 | - | 0 | 1 | |||
| Nfatc3 | intron | 25 | - | 0 | 1 | AKV | B cell | |
| Parp1 | 38 | - | 1 | 0 | LBC, IBC, DC | |||
| Ror1 | intron | 60 | - | 0 | 1 | |||
| Tcf7l2 | 14, −66 | ++++ | 0 | 2 | ||||
| Wnt1/ Wnt10b | - | 6 | 10 | MMTV | Mammary | |||
| Wnt3/Wnt9b | intron | - | 5 | 0 | MMTV | Mammary | IDC | |
| Wnt3a/Wnt9a | exon (1) | - | 4 | 1 | MMTV | Mammary | ||
| Fgf pathway | ||||||||
| Fgf3/Fgf4 | - | 11 | 8 | MMTV | Mammary | |||
| Fgf8 | - | 2 | 2 | MMTV | Mammary | |||
| Fgfr1 | - | 0 | 2 | |||||
| Fgfr2 | Intron (2) | - | 2 | 2 | IDC, DC | |||
| Fgfr3 | - | 0 | 1 | M-MLV, AKV | B, T cell | |||
| Other | ||||||||
| Arhgap18 | 5, 0.4 | + | 0 | 2 | IBC | |||
| Bai3 | Intron (1) | 91 (I), 126 | - | 0 | 2 | |||
| Igf2/Ins2 | 1, 6, 9 | + | 2 | 1 | MMTV | Mammary | ||
| Pdgfra | Intron (1) | 2 (I), 1 | - | 0 | 2 | |||
| Prkaca | Intron (1) | 6 (I), 30 | +++ | 0 | 2 | |||
*Distance in kb from start of transcription for CIS other than Wnt or Fgf genes.
**expression in normal mammary tissue (data from BioGPS).
+
number of BALB and C3H tumors with this CIS.
#
data from Oncomine database. Abbreviations: HBC, human breast cancer; LBC, lobular breast carcinoma; IBC, invasive breast carcinoma; ILC, invasive lobular carcinoma; DBC ductal carcinoma.