Figure 5. OVA-specific Ab responses in CD4dnTGFβRII mice after large-dose oral tolerance and oral challenge with OVA plus CT.

A-C. One week after the last challenge, plasma and fecal extracts were subjected to OVA-specific ELISA to determine IgG, IgA (plasma; A, B) or S-IgA (fecal extract; C). Endpoint titers are expressed as the last dilution yielding OD₄₁₅ of > 0.1 units above background control values. For CD4dnTGFβRII experiments: n = 8 OVA-fed, n = 5 PBS controls. For wild-type experiments: n = 19 OVA-fed, n = 8 PBS controls. **p<0.001.