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. Author manuscript; available in PMC: 2012 Jun 1.
Published in final edited form as: J Pediatr. 2010 Dec 30;158(6):947–952.e1-3. doi: 10.1016/j.jpeds.2010.11.026

Table III.

Test performance characteristics of specific HbA1c thresholds for detecting diabetes according to fasting plasma glucose (FPG) and prediabetes according to FPG or 2-hour plasma glucose (2-hr PG) in adolescents and adults. At certain HbA1c thresholds there were no individuals with those HbA1c values.

Diabetes (FPG), Adolescents Diabetes (FPG), Adults
HbA1c
Threshold		 Sensitivity
(True-
Positive
Rate)		 Specificity
(True-
Negative
Rate)		 Positive
Likelihood
Ratio		 Positive
Predictive
Value		 Negative
Predictive
Value		 Sensitivity
(True-
Positive
Rate)		 Specificity
(True-
Negative
Rate)		 Positive
Likelihood
Ratio		 Positive
Predictive
Value		 Negative
Predictive
Value
3.6 - - - - - 1.00 0.00 1.00 0.04
3.8 - - - - - 1.00 0.00 1.00 0.04 1.00
4.0 1.00 0.00 1.00 0.00 1.00 0.00 1.00 0.04 1.00
4.1 1.00 0.00 1.00 0.00 1.00 1.00 0.00 1.00 0.04 1.00
4.2 - - - - - 1.00 0.00 1.00 0.04 1.00
4.3 1.00 0.00 1.00 0.00 1.00 1.00 0.00 1.00 0.04 1.00
4.4 1.00 0.01 1.01 0.00 1.00 1.00 0.01 1.01 0.04 1.00
4.5 1.00 0.01 1.01 0.00 1.00 1.00 0.01 1.01 0.04 0.98
4.6 1.00 0.02 1.02 0.00 1.00 0.99 0.02 1.01 0.04 0.98
4.7 1.00 0.03 1.04 0.00 1.00 0.99 0.03 1.02 0.04 0.99
4.8 1.00 0.06 1.06 0.00 1.00 0.99 0.05 1.04 0.04 0.99
4.9 1.00 0.10 1.11 0.00 1.00 0.99 0.09 1.09 0.04 1.00
5.0 1.00 0.17 1.20 0.00 1.00 0.99 0.15 1.16 0.04 1.00
5.1 1.00 0.31 1.44 0.00 1.00 0.99 0.23 1.28 0.05 1.00
5.2 1.00 0.46 1.86 0.01 1.00 0.98 0.33 1.46 0.05 1.00
5.3 0.75 0.61 1.92 0.01 1.00 0.98 0.44 1.75 0.06 1.00
5.4 0.75 0.74 2.94 0.01 1.00 0.95 0.56 2.17 0.07 1.00
5.5 0.75 0.85 5.11 0.02 1.00 0.93 0.67 2.82 0.09 1.00
5.6 0.75 0.93 10.05 0.03 1.00 0.89 0.77 3.87 0.12 0.99
5.7 0.75 0.96 18.38 0.06 1.00 0.88 0.84 5.56 0.17 0.99
5.8 0.75 0.98 37.57 0.12 1.00 0.86 0.89 8.13 0.23 0.99
5.9 0.75 0.99 72.00 0.20 1.00 0.80 0.93 11.00 0.29 0.99
6.0 0.75 1.00 172.80 0.38 1.00 0.75 0.95 16.05 0.37 0.99
6.1 0.75 1.00 287.99 0.50 1.00 0.73 0.97 23.96 0.47 0.99
6.2 0.75 1.00 432.01 0.60 1.00 0.67 0.98 31.92 0.54 0.99
6.3 - - - - - 0.63 0.99 53.90 0.67 0.99
6.4 - - - - - 0.59 0.99 73.56 0.73 0.98
6.5 0.75 1.00 863.98 0.75 1.00 0.54 0.99 102.93 0.79 0.98
6.6 - - - - - 0.49 1.00 151.15 0.85 0.98
6.7 0.50 1.00 575.99 0.67 1.00 0.46 1.00 165.79 0.86 0.98
6.8 - - - - - 0.43 1.00 254.03 0.90 0.98
6.9 - - - - - 0.39 1.00 255.03 0.90 0.98
7.0 - - - - - 0.35 1.00 288.24 0.91 0.98
7.1 0.50 1.00 - 1.00 1.00 0.34 1.00 313.94 0.92 0.98
7.5 - - - - - 0.29 1.00 474.78 0.95 0.97
8.0 - - - - - 0.23 1.00 379.82 0.93 0.97
8.4 - - - - - 0.20 1.00 664.69 0.96 0.97
9.0 - - - - - 0.16 1.00 1000.00 0.97 0.97
9.3 0.25 1.00 - 1.00 1.00 - - - - -
9.4 - - - - - 0.13 1.00 868.17 0.97 0.97
10.0 - - - - - 0.11 1.00 732.52 0.96 0.97
10.4 - - - - - 0.11 1.00 705.39 0.96 0.97
10.9 - - - - - 0.09 1.00 596.87 0.96 0.97
11.5 - - - - - 0.06 1.00 1.00 0.97
11.9 - - - - - 0.04 1.00 1.00 0.97
12.4 - - - - - 0.03 1.00 1.00 0.97
12.9 - - - - - 0.01 1.00 1.00 0.96
13.5 - - - - - 0.01 1.00 1.00 0.96
14.0 - - - - - 0.00 1.00 1.00 0.96
Prediabetes (FPG), Adolescents Prediabetes (FPG), Adults
HbA1c
Threshold		 Sensitivity
(True-
Positive
Rate)		 Specificity
(True-
Negative
Rate)		 Positive
Likelihood
Ratio		 Positive
Predictive
Value		 Negative
Predictive
Value		 Sensitivity
(True-
Positive
Rate)		 Specificity
(True-
Negative
Rate)		 Positive
Likelihood
Ratio		 Positive
Predictive
Value		 Negative
Predictive
Value
3.6 - - - - - 1.00 0.00 1.00 0.35
3.8 - - - - - 1.00 0.00 1.00 0.35 0.00
4.0 1.00 0.00 1.00 0.16 1.00 0.00 1.00 0.35 0.50
4.1 1.00 0.00 1.00 0.16 1.00 1.00 0.00 1.00 0.35 0.71
4.2 - - - - - 1.00 0.00 1.00 0.35 0.73
4.3 1.00 0.01 1.01 0.16 1.00 1.00 0.00 1.00 0.35 0.85
4.4 1.00 0.01 1.01 0.16 1.00 1.00 0.01 1.00 0.35 0.83
4.5 1.00 0.01 1.01 0.16 1.00 1.00 0.01 1.01 0.35 0.82
4.6 1.00 0.02 1.03 0.16 1.00 0.99 0.02 1.01 0.35 0.83
4.7 0.99 0.04 1.03 0.16 0.95 0.99 0.03 1.02 0.35 0.86
4.8 0.97 0.07 1.04 0.17 0.93 0.98 0.06 1.05 0.36 0.87
4.9 0.94 0.10 1.04 0.17 0.89 0.97 0.11 1.09 0.37 0.87
5.0 0.89 0.18 1.08 0.17 0.89 0.94 0.19 1.16 0.38 0.85
5.1 0.78 0.32 1.15 0.18 0.88 0.90 0.28 1.26 0.40 0.84
5.2 0.66 0.48 1.29 0.20 0.88 0.86 0.41 1.45 0.43 0.84
5.3 0.52 0.63 1.43 0.21 0.87 0.77 0.53 1.65 0.47 0.81
5.4 0.38 0.77 1.65 0.24 0.87 0.68 0.66 1.99 0.51 0.79
5.5 0.24 0.87 1.80 0.26 0.86 0.58 0.77 2.58 0.58 0.78
5.6 0.16 0.94 2.67 0.34 0.85 0.46 0.86 3.27 0.63 0.75
5.7 0.11 0.97 3.80 0.42 0.85 0.37 0.92 4.45 0.70 0.73
5.8 0.06 0.99 4.50 0.46 0.85 0.30 0.95 6.33 0.77 0.72
5.9 0.04 0.99 6.00 0.53 0.84 0.23 0.97 8.04 0.81 0.70
6.0 0.03 1.00 8.75 0.63 0.84 0.18 0.99 12.02 0.86 0.69
6.1 0.02 1.00 10.50 0.67 0.84 0.14 0.99 17.54 0.90 0.69
6.2 0.02 1.00 21.00 0.80 0.84 0.12 1.00 24.69 0.93 0.68
6.3 - - - - - 0.09 1.00 45.66 0.96 0.67
6.4 - - - - - 0.08 1.00 58.75 0.97 0.67
6.5 0.02 1.00 15.75 0.75 0.84 0.07 1.00 59.57 0.97 0.67
6.6 - - - - - 0.06 1.00 50.14 0.96 0.67
6.7 0.01 1.00 10.50 0.67 0.84 0.05 1.00 58.44 0.97 0.67
6.8 - - - - - 0.05 1.00 51.84 0.96 0.66
6.9 - - - - - 0.04 1.00 47.13 0.96 0.66
7.0 - - - - - 0.04 1.00 41.94 0.96 0.66
7.1 0.01 1.00 1.00 0.84 0.04 1.00 39.59 0.95 0.66
7.5 - - - - - 0.03 1.00 32.99 0.95 0.66
8.0 - - - - - 0.02 1.00 26.39 0.93 0.66
8.4 - - - - - 0.02 1.00 46.18 0.96 0.66
9.0 - - - - - 0.02 1.00 71.64 0.97 0.66
9.3 0.01 1.00 1.00 0.84 - - - - -
9.4 - - - - - 0.01 1.00 60.33 0.97 0.66
10.0 - - - - - 0.01 1.00 50.90 0.96 0.66
10.4 - - - - - 0.01 1.00 49.02 0.96 0.66
10.9 - - - - - 0.01 1.00 41.48 0.96 0.66
11.5 - - - - - 0.01 1.00 1.00 0.65
11.9 - - - - - 0.00 1.00 1.00 0.65
12.4 - - - - - 0.00 1.00 1.00 0.65
12.9 - - - - - 0.00 1.00 1.00 0.65
13.5 - - - - - 0.00 1.00 1.00 0.65
14.0 - - - - - 0.00 1.00 1.00 0.65
Prediabetes (2-hr PG), Adolescents Prediabetes (2-hr PG), Adults
HbA1c
Threshold		 Sensitivity
(True-
Positive
Rate)		 Specificity
(True-
Negative
Rate)		 Positive
Likelihood
Ratio		 Positive
Predictive
Value		 Negative
Predictive
Value		 Sensitivity
(True-
Positive
Rate)		 Specificity
(True-
Negative
Rate)		 Positive
Likelihood
Ratio		 Positive
Predictive
Value		 Negative
Predictive
Value
3.8 - - - - - 1.00 0.00 1.00 0.22
4.0 1.00 0.00 1.00 0.07 1.00 0.00 1.00 0.22 1.00
4.1 1.00 0.02 1.02 0.08 1.00 1.00 0.00 1.00 0.22 1.00
4.2 - - - - - 1.00 0.01 1.01 0.22 1.00
4.3 - - - - - 1.00 0.01 1.01 0.22 1.00
4.4 1.00 0.02 1.02 0.08 1.00 1.00 0.01 1.01 0.22 1.00
4.5 1.00 0.02 1.02 0.08 1.00 0.99 0.02 1.01 0.22 0.88
4.6 1.00 0.04 1.05 0.08 1.00 0.98 0.03 1.02 0.22 0.88
4.7 0.95 0.06 1.01 0.08 0.94 0.98 0.05 1.03 0.22 0.90
4.8 0.85 0.09 0.94 0.07 0.88 0.96 0.09 1.06 0.22 0.89
4.9 0.80 0.16 0.95 0.07 0.91 0.95 0.15 1.12 0.23 0.91
5.0 0.75 0.25 1.00 0.07 0.92 0.92 0.22 1.17 0.24 0.90
5.1 0.70 0.37 1.11 0.08 0.94 0.89 0.30 1.27 0.26 0.91
5.2 0.50 0.53 1.06 0.08 0.93 0.84 0.40 1.40 0.28 0.90
5.3 0.40 0.66 1.19 0.09 0.93 0.80 0.50 1.61 0.31 0.90
5.4 0.40 0.76 1.67 0.12 0.94 0.72 0.62 1.89 0.34 0.89
5.5 0.15 0.86 1.06 0.08 0.93 0.63 0.70 2.11 0.37 0.87
5.6 0.05 0.90 0.51 0.04 0.92 0.55 0.79 2.60 0.42 0.86
5.7 0.05 0.96 1.24 0.09 0.93 0.47 0.86 3.39 0.48 0.86
5.8 0.00 0.98 0.00 0.00 0.92 0.36 0.91 4.02 0.52 0.84
5.9 0.00 0.99 0.00 0.00 0.92 0.28 0.94 4.89 0.57 0.83
6.0 0.00 1.00 0.00 0.00 0.92 0.24 0.96 6.84 0.65 0.82
6.1 - - - - - 0.19 0.98 9.10 0.71 0.81
6.2 - - - - - 0.15 0.99 10.50 0.74 0.81
6.3 - - - - - 0.13 1.00 29.86 0.89 0.81
6.4 - - - - - 0.10 1.00 23.31 0.86 0.80
6.5 - - - - - 0.09 1.00 36.42 0.91 0.80
6.6 - - - - - 0.07 1.00 41.88 0.92 0.80
6.7 - - - - - 0.07 1.00 76.47 0.95 0.80
6.9 - - - - - 0.06 1.00 65.55 0.95 0.79
7.0 - - - - - 0.05 1.00 1.00 0.79
7.6 - - - - - 0.05 1.00 1.00 0.79
8.0 - - - - - 0.04 1.00 1.00 0.79
8.8 - - - - - 0.04 1.00 1.00 0.79
9.2 - - - - - 0.03 1.00 1.00 0.79
9.6 - - - - - 0.03 1.00 1.00 0.79
10.0 - - - - - 0.02 1.00 1.00 0.79
10.6 - - - - - 0.02 1.00 1.00 0.79
11.2 - - - - - 0.01 1.00 1.00 0.79
12.8 - - - - - 0.00 1.00 1.00 0.79