Table 2.
Summary of the literature review of oral and oropharyngeal lymphoepithelial carcinoma (LEC) including our case (case 2)
| Report | Age/sex | Tumor site/size | Duration of symptoms | Local spread | Metastases | Treatment | EBV | Follow up | Relapse or residual, metastases |
|---|---|---|---|---|---|---|---|---|---|
| Case 2 | 49/M | Soft palate and uvula/2 × 2 cm | 6 mo | No | Neck | SR + R neck | – | 10 mo | No |
| Merz [17] | 73/F | Base of tongue | 2 mo | No | n/a | RC | n/a | n/a | n/a |
| Shet [18] | 11/M | Mandible | 3 mo | Yes | Neck | CR | + | 36 mo | No |
| Mahomed [19] | 73/M | Lower lip midline/1 × 1 cm | 4 mo | No | No | S | – | 20 mo | No |
| Lee [20] | 66/M | Tonsil, R, 2 × 3 × 4.5 cm | 4 mo | Yes | Lung | CR | n/a | 11 mo | No |
| Hsiung [21] | 50/F | Minor salivary gland in right buccal area/T1 | n/a | n/a | No | SR | n/a | 116,5 mo | n/a |
| Lu [22] | 50/F | Minor salivary gland, cheek/2 × 1.6 × 1 cm | 12 mo | No | No | SR | + | 120 mo | No |
| Wakisaka [23] | 62/M | Buccal mucosa, tongue base | 2 mo | Yes | Nodal | SR + R neck | n/a | 20 mo | No |
| Chow [24] | 58/M | Palatinum/2 cm | 18 mo | No | Neck | R + R neck | + | 30 mo | No |
| 56/F | Palatinum/1.5 cm | 12 mo | No | No | R + R neck | + | 12 mo | No | |
| 80/F | Retromolar region | 1 mo | No | Neck | Patient refused | + | 34 mo | Died | |
| Hidaka [25] | 60/M | Tonsil, right | 3 mo | No | Neck | CR + R neck | – | 22 mo | No |
| Ahuja [26] | 66/F | Soft palate | n/a | No | Neck | n/a | + | n/a | n/a |
| 63/M | Roof of the oral cavity/2,5 cm | 36 mo | n/a | n/a | n/a | + | n/a | n/a | |
| 47/F | Palatinum | n/a | Yes | Yes | n/a | + | n/a | n/a | |
| 51/M | Nasal cavity and palatinum | n/a | Yes | No | n/a | + | n/a | n/a | |
| Worley [27] | 69/F | Subepithelial mass,buccal mandibula/0.5 cm | 3 mo | No | Neck | SR | – | 12 mo | No |
| Evans [28] | 68/F | Soft palate and uvula,minor salivary glands | 1 mo | No | Neck | R + R neck | n/a | n/a | No |
| Bansberg [29] | 51/F | Tongue base, R/T2 | n/a | No | N2 | R | n/a | 63 mo | Died |
| 66/F | Tongue base, L/T1 | n/a | No | N1 | SR | n/a | 87 mo | Died, unrelated cause | |
| 44/F | Tonsil, L/T2 | n/a | No | N0, M1 | R | n/a | 2 mo | Died | |
| 78/F | Tonsil, L/T3 | n/a | No | N2a | R | n/a | 34 mo | Died, lung | |
| 45/F | Tonsil, L/T1 | n/a | No | No | R | n/a | 8 mo | Died, L neck, liver | |
| 62/F | Tongue base, L/T1 | n/a | No | N1 | R | n/a | 120 mo | No | |
| 65/M | Tongue base, R/T1 | n/a | No | N2b | R + S neck | n/a | 108 mo | No | |
| 40/F | Tonsil, L/T2 | n/a | No | no | R | n/a | 190 mo | No | |
| 64/M | Tongue base, M/T2 | n/a | No | N2 | R | n/a | 180 mo | No | |
| 28/F | Tongue base, R/T2 | n/a | No | N1 | R | n/a | 46 mo | Died, tongue, lung | |
| 65/M | Tonsil, R/T3 | n/a | No | N2a | R | n/a | 120 mo | No | |
| 75/M | Tongue base, L/T2 | n/a | No | N2a | R | n/a | 18 mo | Died, R neck, liver | |
| 53/M | Tonsil, R/T1 | n/a | No | N2a | SR + S neck | n/a | 64 mo | No |
EBV Epstein-barr virus, M male, F female, mo months, S surgery, R radiotherapy, C chemotherapy, + positive, − negative, n/a not available