Table 6.

Effect of GII (50 mg/kg bw) administration for 15 days on hexokinase and glucokinase in the liver, muscle and kidneys of the subdiabetic, moderately diabetic and severely diabetic rabbits

Hexokinase (u/g tissue)	Liver	Muscle	Kidneys
Normal	0.7 ± 0.05	2.7 ± 0.2	0.9 ± 0.06
Subdiabetic untreated	0.62 ± 0.05 (9% fall from normal)	2.46 ± 0.1 (9% fall from normal)	0.9 ± 0.05 (no change)
Subdiabetic treated (change% from untreated)	0.67 ± 0.04 (+8%)	2.67 ± 0.1 (+8.5%)	0.9 ± 0.04 (no change)
Moderately diabetic untreated	0.46 ± 0.05 (34% fall from normal)	1.12 ± 0.12 (55%) fall from normal	0.9 ± 0.04 (no change)
Moderately diabetic treated (change% from untreated)	0.64 ± 0.04 (+39%)	1.54 ± 0.13 (+38%)	1.0 ± 0.04 (+11%)
Severely diabetic Untreated	0.47 ± 0.03 (34% fall from normal)	1.0 ± 0.1 (63% fall from normal)	0.77 ± 0.03 (14% fall from normal)
Severely diabetic treated (change% from untreated)	0.59 ± 0.04 (+25%)	1.47 ± 0.15 (+47%)	0.93 ± 0.05 (+21%)

Glucokinase (u/g tissue)	Liver
Normal	1.7 ± 0.07
Subdiabetic untreated	0.68 ± 0.04 (60% fall from normal)
Subdiabetic treated (change% from untreated)	1.76 ± 0.08 (+159%)
Moderately diabetic untreated	0.32 ± 0.03 (81% fall from normal)
Moderately diabetic treated (change% from untreated)	1.68 ± 0.07 (+425%)
Severely diabetic untreated	0.35 ± 0.03 (79% fall from normal)
Severely diabetic treated (change% from untreated)	1.70 ± 0.08 (+386%)