Table 7.
Effect of 15 days treatment of GII on the pyruvate kinase in the liver, muscle and kidneys, malic enzyme in the liver and kidneys of the subdiabetic, moderately and severely diabetic rabbits and glucose-6-phosphate dehydrogenase in the liver of the moderately and severely diabetic rabbits
| Pyruvate kinase (u/g) | Liver | Muscle | Kidneys |
|---|---|---|---|
| Normal | 25.9 ± 2 | 28.9 ± 2 | 12.2 ± 0.6 |
| Subdiabetic untreated | 24.8 ± 3 | 28.8 ± 9 | 12.1 ± 0.7 |
| Subdiabetic treated (change% from untreated) | 25.9 ± 2 (+4%) | 27.1 ± 1 (-5%) | 12.2 ± 0.6 (+1%) |
| Moderately diabetic untreated | 19.4 ± 1 (22% fall from normal) | 18.3 ± 1 (37% fall from normal) | 12.2 ± 0.8 (No change) |
| Moderately diabetic treated (change% from untreated) | 26.2 ± 2 (+35%) | 28.1 ± 2 (+54%) | 12.3 ± 0.7 (+1%) |
| Severely diabetic untreated | 17.2 ± 1 (36% fall from normal) | 21.9 ± 0.9 (24% fall from normal) | 10.0 ± 1 (18% fall from normal) |
| Severely diabetic treated (change% from untreated) | 25.1 ± 2 (+46%) | 27.1 ± 1 (24%) | 11.9 ± 0.8 (+19%) |
| Malic enzyme (u/g) | Liver | Kidneys |
|---|---|---|
| Normal | 1.10 ± 0.07 | 1.62 ± 0.1 |
| Subdiabetic untreated | 1.08 ± 0.08 (no change) | 1.11 ± 0.09 (32% fall from normal) |
| Subdiabetic treated (change% from untreated) | 1.12 ± 0.04 (+4%) | 1.06 ± 0.08 (−5%) |
| Moderately diabetic untreated | 0.59 ± 0.04 (46% fall from normal) | 1.04 ± 0.07 (36% fall from normal) |
| Moderately diabetic treated (change% from untreated) | 1.09 ± 0.08 (+85%) | 0.99 ± 0.08 (−5%) |
| Severely diabetic untreated | 0.58 ± 0.04 (47% fall from normal) | 1.01 ± 0.08 (39% fall from normal) |
| Severely diabetic treated (change% from untreated) | 1.01 ± 0.07 (+74%) | 1.07 ± 0.08 (+6%) |