Table 9.
Effect of GII (50 mg/kg bw) treatment for 15 and 30 days on the enzymes of polyol pathway in the liver of the subdiabetic, moderately diabetic and severely diabetic rabbits
| Kidneys | Liver | |
|---|---|---|
| Sorbitol dehydrogenase (u/g tissue) | ||
| Normal | 6.6 ± 0.6 | 9.4 ± 0.6 |
| Subdiabetic untreated | 6.8 ± 0.6 | 9.1 ± 0.6 |
| Subdiabetic treated (15 days) | 6.5 ± 0.5 (−4%) | 9.3 ± 0.7 (+2%) |
| Moderately diabetic untreated | 8.0 ± 0.6 | 9.9 ± 0.8 |
| Moderately diabetic treated (15 days) | 6.8 ± 0.5 (−15%) | 9.3 ± 0.5 (−6%) |
| Severely diabetic untreated | 8.6 ± 0.8 | 10.7 ± 0.7 |
| Severely diabetic treated (15 days) | 7.2 ± 0.6 (−16%) | 9.9 ± 0.6 (−7%) |
| Severely diabetic untreated (30 days) | 10.7 ± 0.7 | 8.6 ± 0.8 |
| Severely diabetic treated (30 days) | 9.8 ± 0.7 (−9%) | 6.5 ± 6 (−24%) |
| Aldose reductase (u/g tissue) | ||
| Normal | 0.21 ± 0.4 | 0.29 ± 0.05 |
| Sub diabetic untreated | 0.26 ± 0.06 | 0.29 ± 0.04 |
| Sub diabetic treated (15 days) | 0.23 ± 0.04 (−12%) | 0.28 ± 0.03 (−4%) |
| Moderately diabetic untreated | 0.27 ± 0.06 | 0.33 ± 0.04 |
| Moderately diabetic treated (15 days) | 0.22 ± 0.08 (−15%) | 0.27 ± 0.03 (−18%) |
| Severely diabetic untreated | 0.30 ± 0.08 | 0.33 ± 0.05 |
| Severely diabetic treated (15 days) | 0.23 ± 0.07 (−23%) | 0.28 ± 0.07 (−15%) |
| Severely diabetic untreated (30 days) | 0.28 ± 0.07 | 0.35 ± 0.08 |
| Severely diabetic treated (30 days) | 0.26 ± 0.03 | 0.21 ± 0.05 (−40%) |