Figure 3.

Schematic diagram for influence of neurogenesis by sAPPα and AICD. The α-secretases cleavage of APP could release sAPPα into extracellular space, which could function on cells possibly via binding with its specific receptors. The sAPPα could function to promote NPC proliferation and positively regulate neurogenesis. On the contrary, γ-secretases cleavage of APP could release AICD into cytoplasm, which could complex with Fe65 and enter nucleus. The AICD and Fe65 complex might function to transcriptionally regulate gene expressions related to neurogenesis, including miRNAs genes. Finally AICD will function to inhibit neuronal differentiation via so far unknown mechanisms, hereby negatively regulate neurogenesis.