Figure 5.

Flow chart summarization of potential pathogenesis of AD related to APP. The altered APP processing could contribute to Aβ accumulation, increased AICD and decreased sAPP. The increased AICD and decreased sAPP could finally lead to decreased neurogenesis, while decreased sAPP could also facilitate neurodegeneration. The Aβ accumulation could lead to Aβ senile plaques and induce calcium flux via a tau protein-dependent manner. The dysregulated intracellular calcium and increased ROS level finally contribute to neurodegeneration. Hereby the decreased neurogenesis and increased neuron degeneration contribute to AD.