Figure 6.

The proposed secretase balances related to AD pathogenesis. The balance between α- and β-secretase will determine Aβ protein and sAPPα formation and cell viability influenced by Aβ or sAPPα. The disruption of this secretase balance could lead to decreased sAPPα production and increased Aβ accumulation and neurons degeneration. The balance between α- and γ-secretase will influence neurogenesis. The disruption of this balance might contribute to impaired neurogenesis in brain. The imbalance of these secretase balances could contribute to AD. The miR-298 and miR-328 was reported to control β-secretase expression. Therefore dysregulation of these miRNAs might lead to imbalance between α- and β-secretase and be even related to AD. So far miRNAs for α- and γ-secretase have not been identified. Studies on them should be interesting in the future.