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NRP1 knockdown reduces apoptosis induced by doxorubicin in VEGF189 overexpressing clones. V189 (A), n = 6, V165 (B), n = 5 and cV clones (C), n = 7 have been transfected with shNRP-1 vs. irrelevant control shRNA clones. Apoptosis assay was performed on cells harvested after 24 h treatment with 2.5 µM doxorubicin in serum-containing medium. Histograms of means (±SE M) stand obtained with the same clones, as shown in Figure 5, are presented. *p ≤ 0.05 vs. corresponding shCtl clone.
