Cosmosiin (Cos) and liquiritigenin (Liq) inhibit the growth of Hs578T-ERβ cells. Hs578T-ERα (A, C, E) and Hs578T-ERβ cells (B, D, F) were seeded in 6 well plates and treated with vehicle (A, B) or 50 ng/mL Dox (C, D). After 24 hr, the cells were treated with vehicle (0.1% DMSO) or the indicated ligands, and treatments were refreshed every 48 hr. Cells were counted at the times indicated using trypan blue exclusion. Comparisons of the cell number on day 5 are represented in panels E (Hs578T-ERα) and F (Hs578T-ERβ). Data represent two independent experiments. * p values < 0.05