Table 1.

Correlation between predicted, pri-miRNA structures and Drosha cleavage or miRNA expression

Structure (by ΔG, kcal/mol)	Cleavage efficiency			miRNA expression			miRNA expression (all)
	n	ρ	p	n	ρ	p	n	ρ	p
Proximal domain	247	-0.261	0.0001	232	-0.352	0.000001	435	-0.239	0.00003
Distal domain	246	0.118	0.066	231	-0.001	0.89	434	0.053	0.27
miRNA duplex	246	-0.039	0.54	231	-0.123	0.062	434	-0.119	0.013
pre-miRNA	247	0.111	0.081	232	0.049	0.46	435	0.010	0.84
pri-miRNA	246	-0.051	0.42	231	-0.175	0.008	434	-0.148	0.002
Terminal loop region	246	0.253	0.0002	231	0.269	0.00004	434	0.192	0.0001

Sample size (n), Spearman’s correlation coefficient (ρ), and p-values are listed. For results of the secondary structure prediction, see Supplementary Tables S4 and 5. Sequence reads of those human miRNAs shown in Supplementary Table S2 as well as of all the human miRNAs [9] were both used for the correlation studies.