Figure 4. CtpS regulates cell shape through an interaction with crescentin.
(a–d) Cell morphology of Caulobacter cells with wild-type (a and b) and depleted (c and d) CtpS levels in a background either with creS (a and c, creS+, ZG215) or without creS (b and d, ΔcreS, ZG216). (e–f) Localization of Caulobacter mCherry-CtpS (red) in creS+ (e, ZG287) and ΔcreS (f, ZG285) backgrounds. Merged fluorescent images are shown, and the cell periphery is marked with a gfp fusion (green) to the periplasmic protein encoded by CC2395. (g) ECT filaments in ΔcreS cells (ZG17). Arrows point to filaments ends. (h–i) Co-localization of Caulobacter mCherry-CtpS (red) and CreS-tc (green) in both Caulobacter (h, ZG218) and upon heterologous co-expression in E.coli (i, ZG221). White scale bars represent 2 μm, black scale bars represent 100 nm.