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. 2010 Apr 6;88(1):181–188. doi: 10.1189/jlb.1009691

Figure 2.

Figure 2

Phenotypic analysis of MoDCs treated with KCC009, a small-molecule TG2 inhibitor. Human DCs were generated from monocytes (mDC) after 5 days of culture with GM-CSF and IL-4 and in the presence of different concentrations of KCC009. Then, cells were treated with LPS for 24 h, and mature DC (mDC) phenotype was analyzed. (A) The expression of the indicated molecules (as histograms) of a representative experiment. (B) The effect of KCC009 on DC maturation obtained from all of the experiments is represented. The results are shown as percentage of the increase of molecule expression in the LPS-treated DCs upon treatment with different concentrations of KCC009.