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. 2011 Nov 8;6(11):e27514. doi: 10.1371/journal.pone.0027514

Figure 5. Steady-state concentration of free VEGF.

Figure 5

(A) The steady-state concentration of VEGF in the tissue compartment but not in the blood is highly dependent on the VEGF secretion rate. (B) The VEGF concentration in the blood is more sensitive to the VEGF plasma clearance rate than the VEGF concentration in the tissue. (C) As microvascular permeability of VEGF increases, VEGF concentrations in the tissue and blood compartments equilibrate to 2.25 pM. For all simulations, unless the parameter is varied: VEGF164 secretion rate qV164  =  0.063 molecules/cell/s (optimized value), plasma clearance rate cV  =  0.23 min−1, and permeability kp  =  4.0×10−8 cm/s.