Skip to main content
. 2011 Nov 8;6(11):e27514. doi: 10.1371/journal.pone.0027514

Figure 9. VEGF distributions upon injection of anti-VEGF (VEGF Trap).

Figure 9

The distributions of VEGF in the (A) blood and (B) tissue compartments are shown subject to a 25 mg/kg injection of the anti-VEGF agent into the blood compartment at 0 weeks. Before the injection, 95% of VEGF in the blood compartment is receptor bound. In the tissue compartment, 38% of VEGF is sequestered in the extracellular matrix and endothelial and parenchymal basement membranes. 60% of VEGF is receptor-bound. Shortly following the injection of the anti-VEGF agent, essentially all of the VEGF in both compartments becomes sequestered by the anti-VEGF agent. By 14 weeks, VEGF distributions return to original steady-state levels.