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. 2011 Nov 8;6(11):e27514. doi: 10.1371/journal.pone.0027514

Figure 10. VEGF Receptor fractional occupancies upon injection of anti-VEGF (VEGF Trap).

Figure 10

The fractional occupancies of (A) VEGFR-1, (B) VEGFR-2, and (C) NRP-1 are shown for the blood (red) and tissue (blue) compartments following a 25 mg/kg injection of the anti-VEGF agent into the blood compartment at 0 weeks. For all three receptors in the blood compartment, the percent of receptors ligated with VEGF decreases to essentially zero quickly after the injection of the anti-VEGF; however, the percent of ligated receptors then increases to values above pre-injection levels before returning to pre-injection levels. In the tissue compartment, this effect is not seen as the percent of ligated receptors decreases quickly after injection and then returns to pre-injection levels. Note that the y-axes of the panels are on different scales.