Table 6. Summary of parameter optimization (n = 20).

	Lower bound	Upper bound	Min	Max	Optimal*	Unit
VEGF164 secretion rate	0.01	0.20	0.0544	0.0647	0.0626	molecules/cell/s
Lymphatic drainage	7.00×10−6	7.00×10−4	7.00×10−6	2.73×10−5	7.00×10−6	cm3/s
Clearance of VEGF Trap	1.60×10−5	1.60×10−3	8.45×10−4	9.38×10−4	8.86×10−4	min−1
Clearance of VEGF/VEGF Trap complex	1.60×10−5	1.60×10−3	2.16×10−4	3.20×10−4	2.79×10−4	min−1
Kd of VEGF and VEGF Trap	0.25	5.00	0.32	0.48	0.37	pM

*Of the 20 trials, the optimal trial was the one that yielded the smallest weighted sum of squared residuals.