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. 2011 Nov 8;6(11):e27494. doi: 10.1371/journal.pone.0027494

Figure 8. Model outputs after blocking positive feedback cycles in the MM-bone model.

Figure 8

(a) Bone volume after blocking positive feedback cycles at specified points. (b) The density of MM cells after blocking positive feedback cycles at specified points. Case 1 Positive feedback cycle A is blocked at the point of interaction of IL-6 and osteoblast precursors. Case 2 Positive feedback cycle B is blocked at the point of interaction between IL-6 and MM cells. Case 3 Positive feedback cycles A and B are simultaneously blocked at the point of IL-6 production by BMSC. Case 4 Positive feedback cycle A is blocked at the point of OPG degradation by MM cells. Case 5 Positive feedback cycle B is blocked at the point of MM-BMSC adhesion-stimulated MM-cell proliferation.