Table 7. The percentages of AUC of bone volume and MM-cell density when positive feedback cycles are blocked to those when these cycles are intact.

	Case 1	Case 2	Case 3	Case 4	Case5
Percentage of AUC of bone volume	6.74%	31.06%	↑	38.47%	78.35%
Percentage of AUC of MM-cell density	79.77%	↓	↓	89.76%	79.4%

Note: case 1: Positive feedback cycle A is blocked at regulation mechanism between IL-6 and osteoblast precursors; case 2: Positive feedback cycle B is blocked at regulation mechanism between IL-6 and MM cells; case 3: Positive feedback cycle A and B are simultaneously blocked at regulation mechanism of IL-6 production; Case 4: additional pathway to positive feedback cycle A is blocked at regulation mechanism of OPG degradation by MM cells. Case5: additional pathway to positive feedback cycle B is blocked at regulation mechanism of MM-BMSC adhesion-stimulated MM-cell proliferation.