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. 2011 Nov 8;6(11):e27548. doi: 10.1371/journal.pone.0027548

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Zhao et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Sequence alignment of SdPI and other Kunitz-type proteins. Identical and similar residues are highlighted by black and gray colors. Predicted disulfide connections are shown with lines. The sequence identities of different Kunitz-type proteins compared with SdPI are shown on the right side. HWTX-XI is a bifunctional toxin isolated from spider. It can block voltage-sensitive K⁺ channels and inhibit trypsin activity. Kalicludine-1 is also a bifunctional toxin isolated from sea anemone. DTX-K is a snake derived Kunitz-type venom peptide with a potent potassium channel blocking function. Conkunitizin-S1 is a potassium channel inhibitor isolated from cone snail. HGE030_Hg1 from the Mexican scorpion Hadrurus gertschi is the only reported hypothetical scorpion-derived Kunitz-type venom peptide. BPTI is the first Kunitz-type protein, identified from bovine pancreas. (B) A minimum evolution (ME) tree of representative Kunitz-type proteins based on the multiple sequence alignment.