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. 2011 Jan 21;52(6):425–439. doi: 10.1002/em.20639

Table I.

Gene Set Enrichment Analysis

Probe

Pathway P value aTotal bChanging
Rank-based test
 Complement and coagulation cascades 0.002 123 18
 Hematopoietic cell lineage 0.002 253 13
 Olfactory transduction 0.003 914 2
 Pantothenate and CoA biosynthesis 0.008 26 1
 Systemic lupus erythematosus 0.013 222 11
 Cytokine-cytokine receptor interaction 0.018 652 33
 gamma-Hexachlorocyclohexane degradation 0.021 27 3
 Neuro active ligand-receptor interaction 0.041 421 3
 Toll-like receptor signaling pathway 0.045 332 11
Design-based test
 Cytokine-cytokine receptor interaction 0.001 652 33
 Pantothenate and CoA biosynthesis 0.001 26 1
 Hematopoietic cell lineage 0.006 253 13
 Complement and coagulation cascades 0.011 123 18
 Systemic lupus erythematosus 0.017 222 11
 ABC transporters 0.018 87 2
 Natural killer cell mediated cytotoxicity 0.018 334 13
 T cell receptor signaling pathway 0.019 352 11
 gamma-Hexachlorocyclohexane degradation 0.026 27 3
 Fc epsilon RI signaling pathway 0.029 243 13
 Asthma 0.032 87 3
 Jak-STAT signaling pathway 0.032 390 10
 Linoleic acid metabolism 0.041 53 6
a

Total indicates the total number of known probes in a given pathway.

b

Changing indicates the number of probes changing in a given pathway following the exposure.