TABLE 5.

Weight Change Since the Age of 18 Through 1980 and Relative Risk of CHD According to Physical Activity Levels, Nurses’ Health Study, 1980 to 2000

	Loss ≥4 kg	Stable	Gain 4 to 10 kg	Gain 10.1 to 19.9 kg	Gain 20 to 39.9 kg	Gain ≥40 kg	P for Trend
All participants
No. of cases	181	407	581	631	456	78
Person-years	133 751	465 754	508 478	376 781	174 487	17 745
Age-adjusted RR	1.49 (1.25, 1.77)	1.00	1.20 (1.06, 1.36)	1.56 (1.37, 1.76)	2.38 (2.08, 2.72)	4.28 (3.36, 5.46)	<0.001
Multivariate RR*	0.94 (0.78, 1.13)	1.00	1.27 (1.12, 1.45)	1.65 (1.45, 1.87)	2.33 (2.03, 2.67)	3.86 (3.02, 4.94)	<0.001
Stratified by physical activity(h/wk)
<3.5	0.92 (0.75, 1.13)	1.00	1.26 (1.09, 1.45)	1.59 (1.38, 1.82)	2.27 (1.96, 2.64)	3.48 (2.66, 4.54)	<0.001
≥3.5	1.07 (0.69, 1.64)	1.00	1.33 (0.99, 1.78)	1.97 (1.46, 2.65)	2.62 (1.83, 3.75)	8.93 (4.69, 16.99)	<0.001

^*Multivariate analyses was adjusted for age (<50, 50 to 54, 55 to 59, 60 to 64, ≥65), BMI at age of 18, smoking status (never, past, current [1 to 14, 15 to 24,

≥25 cigarettes/d], adjusted for the analyses for all women only), parental history of coronary heart disease, postmenopausal status and hormone use (never use, past, current), physical activity (5 categories), aspirin use (<1, 1 to 2, 3 to 6, 7 to 14, 15+/wk), and alcohol consumption (0, 0.1 to 4.9, 5 to 14.9, ≥15 g/d). Physical activity and alcohol consumption were adjusted using 1980 data.