Table 5.
Additive interactive effects of alcohol with selected SNPsa
| homozygous for major allele |
one or two copies of minor allele |
||||
|---|---|---|---|---|---|
| Gene, SNP, major/minor alleles lifetime ethanol (ml) |
# cases/ controls |
Adjusted OR (95% CI)b |
# cases/ controls |
Adjusted OR (95% CI)b |
ICRc (CIBonferroni-corrected) |
| ALDH2, rs2238151, T/C | |||||
| never-drinkers | 50/95 | 1.0 (ref) | 67/184 | 0.7 (0.4–1.1) | 1.9 (0.1–3.8) |
| >0 to <134,699 | 75/173 | 0.5 (0.3–0.9) | 133/293 | 0.6 (0.4–1.0) | |
| 134,699 to <757,550 | 97/138 | 0.8 (0.5–1.3) | 220/222 | 1.2 (0.8–1.9) | |
| 757,550+ | 122/65 | 1.7 (1.0–2.8) | 381/106 | 3.3 (2.0–5.3) | |
| ADH1B, rs1159918, G/T | |||||
| never-drinkers | 49/101 | 1.0 (ref) | 68/179 | 0.9 (0.6–1.5) | 1.0 (−0.9, 3.0) |
| >0 to <134,699 | 80/168 | 0.7 (0.4–1.1) | 129/298 | 0.7 (0.5–1.1) | |
| 134,699 to <757,550 | 107/129 | 1.1 (0.7–1.8) | 211/231 | 1.3 (0.8–2.0) | |
| 757,550+ | 140/58 | 2.4 (1.4–4.1) | 365/115 | 3.3 (2.1–5.4) | |
| ADH7, rs1154460, G/A | |||||
| never-drinkers | 35/65 | 1.0 (ref) | 81/215 | 0.6 (0.4–1.1) | 0.9 (−0.6, 2.4) |
| >0 to <134,699 | 57/131 | 0.5 (0.3–0.9) | 152/334 | 0.6 (0.3–0.9) | |
| 134,699 to <757,550 | 88/111 | 0.8 (0.5–1.4) | 229/249 | 1.0 (0.6–1.6) | |
| 757,550+ | 133/54 | 1.9 (1.1–3.5) | 371/119 | 2.5 (1.5–4.2) | |
| CYP2E1, rs2249695, C/T | |||||
| never-drinkers | 73/136 | 1.0 (ref) | 44/144 | 0.6 (0.4–0.9) | 1.2 (−0.6, 3.0) |
| >0 to <134,699 | 127/253 | 0.6 (0.4–0.9) | 82/213 | 0.5 (0.3–0.8) | |
| 134,699 to <757,550 | 160/178 | 1.1 (0.7–1.6) | 158/181 | 1.0 (0.6–1.4) | |
| 757,550+ | 218/92 | 2.1 (1.4–3.3) | 286/81 | 2.9 (1.8–4.6) | |
Selected SNPs meet two criteria. They have (1) ICR confidence intervals that either don't include 0 or nearly so, after Bonferroni correction, and (2) genotype information on sufficient numbers of cases and controls (at least 10 each) for calculating each of the three ORs highlighted in bold for that SNP. If ICR confidence interval appeared significant but numbers of cases and controls were too sparse, SNP was judged to have insufficient evidence of interaction with alcohol, and was not included in this table.
Odds ratios (ORs) for each SNP*drinking category were calculated from conditional logistic regression models including one SNP coded for dominant genetic model, categorized lifetime ethanol consumption, conditioned on sex, race, and age category, and adjusted for continuous smoking duration rounded to whole years. ORs highlighted in bold were used to calculated the ICR.
Interaction contrast ratios (ICRs) that are statistically significant after Bonferroni correction are highlighted in bold. Bonferroni correction for 64 statistical tests.