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. Author manuscript; available in PMC: 2013 Feb 1.
Published in final edited form as: J Orthop Res. 2011 Aug 4;30(2):296–303. doi: 10.1002/jor.21518

Figure 2.

Figure 2

Jag1 and NICD2 are expressed in identical cell populations that participate in endochondral bone repair during TF. Undifferentiated mesenchymal cells (A) are largely positive (brown staining, black arrows), but expression gradually decreases as cells differentiate into proliferative (B), pre-hypertrophic (C), and hypertrophic chondrocytes (D), and then is re-expressed in terminal hypertrophic chondrocytes (E). Alternative to chondrogenesis, osteogenic cells at various stages of maturity, located in osteoid (F), primary (G) and remodeled bone formation (H) are mostly positive. Note that varying amounts of Jag1 and NICD2 negative cells are present in distinct cell population (white arrows). H&E and SafO images acquired at 200X magnification. Jag1 and NICD2 images acquired at 600X magnification.