Table 3. Expression Levels of DNA Repair Genes.
| Repair Pathway | Gene | HCT 116 | HT 29 |
|---|---|---|---|
| BER | XRCC1 | ↑ | ↑ |
| LIG3 | ↑ | ↑ | |
| NER | ERCC1 | ↑ | ↔ |
| ERCC2 | ↑ | ↑ | |
| ERCC3 | ↑ | ↑ | |
| ERCC4 | ↑ | ↔ | |
| ERCC5 | ↔ | ↔ | |
| ERCC6 | ↑ | ↔ | |
| XPA | ↑ | ↑ | |
| XPC | ↑ | ↑ | |
| HR / NHEJ | XRCC2 | ↑ | ↑ |
| XRCC3 | ↑ | ↑ | |
| XRCC4 | ↑ | ↑ | |
| XRCC6 | ↑ | ↑ | |
| ATM | ↑ | ↑ | |
| RAD51 | ↑ | ↑ | |
| BRCA1 | ↑ | ↑ |
Abbreviations: BER, Base excision repair; NER, Nucleotide excision repair; HR, Homologous recombination; NHEJ, Non-homologous end joining.
↑= Expression level > 2× normal colonic mucosal cells; ↓ = Expression level < ½ normal colonic mucosal cells; ↔ = Expression level equal to normal colonic mucosal cells.