Table 4.
Immunosuppression in SHFV-infected macaques.
Immunosuppression1 | Survivors | Non-Survivors | Significant difference in incidence by Fisher's Exact Test (p-value) | ||||
---|---|---|---|---|---|---|---|
Incidence | Mean days of suppression (days post inoculation) | % reduction (range) | Incidence | Mean days of suppression (days post inoculation) | % reduction (range) | ||
Leukopenia | 7/9 (78%) | 4–12 | 60.2 (36.4–79.0) | 11/16 (69%) | 4–8 | 47.1 (20–79) | 1.0000 |
Lymphocytopenia | 7/9 (78%) | 2–10 | 62.8 (21–79) | 12/16 (75%) | 2–11 | 67.1 (50–82) | 1.0000 |
Monocytopenia | 4/9 (44%) | 4–16 | 67.7 (31.3–87.5) | 14/16 (88%) | 2–9 | 71.6 (47.1–90.3) | 0.0581 |
Neutropenia | 7/9 (78%) | 4–16 | 71.9 (60.1–87.1) | 7/16 (44%) | 4–16 | 65.5 (42.3–94.0) | 0.2077 |
Immunosuppression defined by 20% or greater reduction in cell number post-inoculation.