Table 6.
Summary of Histopathological Findings1
| Organ | Major Finding | Survivor (incidence (%)) | Non-survivor (incidence (%)) | Significant difference in incidence by Fisher's Exact Test (p-value) |
|---|---|---|---|---|
| Lung, Kidney, Liver, Heart, GI Tract | Bacteremia | 1/9 (11%) | 12/16 (75%) | 0.0036 |
| CNS | Meningitis/Encephalitis /myelitis | 4/9 (44%) | 9/16 (56%) | 0.6882 |
| Heart | Myocarditis | 9/9 (100%) | 15/16 (94%) | 1.0000 |
| Kidney | Interstitial Nephritis | 9/9 (100%) | 11/16 (69%) | 0.1225 |
| Liver | Necrotizing Hepatitis | 3/9 (33%) | 6/16 (38%) | 1.0000 |
| Lung | Interstitial Pneumonia Fibrin, Edema | 9/9 (100%) | 11/16 (69%) | 0.1225 |
| Lymph node | Lymphoid Hyperplasia | 9/9 (100%) | 2/16 (13%) | <0.0001 |
| Lymph node | Lymphadenitis/Lymphoid Depletion/Lymphocytolysis | 0/9 (0%) | 12/16 (75%) | <0.0001 |
| Spleen | Lymphoid Hyperplasia | 7/9 (78%) | 1/16 (6%) | <0.0001 |
| Spleen | Splenitis/lymphoid depletion | 0/9 (0%) | 14/16 (88%) | <0.0001 |
| Thymus | Thymocyte depletion with necrosis and mineralization | 0/9 (0%) | 14/16 (88%) | <0.0001 |
1
Criteria evaluated at gross necropsy of all subjects. Survivors were necropsied at end of study on day 36