Associations of GIS variables measured repeatedly between ages 2 and 5 years with concurrent total IgE (log-transformed). Data points and error bars describe the ratio of the geometric means of total IgE and 95% CI, respectively, per an interquartile range increase in the magnitude of the GIS variable, adjusted for sex, ethnicity, presence of smoker in the home, annual income, residential cockroach allergen concentration, residential mouse allergen concentration, age, and age by GIS variable interaction.