Table 3.

Summary of previously reported associations between CP and polymorphisms in inflammatory, thrombotic and apolipoprotein E genes, juxtaposed with results of similar analyses performed in the current study. Significant findings without adjustment for multiple comparisons highlighted in bold.

	Previous Studies						Current Study N= 138 White, ≥ 37 weeks
	CP	Gest	Demo-	CP	Rare Homozygote vs. Common Homozygote	Heterozygote vs. Common Homozygote	CP	Rare Homozygote vs. Common Homozygote	Heterozygote vs. Common Homozygote*
Gene (codon)	(N )	Age (wk)	graphics	Typ e**	OR (95% CI)	OR (95% CI)	Typ e	OR (95% CI)	OR (95% CI)
Inflammatory
TNF-alpha -308 (8)	65	≥ 37	Whites	QP	0.0 (0.0–1.6)	1.8 (1.04–3.2)	All	1.9 (0.4–8.0)	0.8 (0.5–1.3)
IL-8 -251 (6)	153	< 37	Whites	All	2.4 (1.3–4.4)	2.0 (1.2–3.5)†	All	1.3 (0.7–2.5)	1.1 (0.7–1.9)
	121	All	Whites	DP	0.8 (0.5–1.3)†	1.9 (1.2–3.1)	DP	1.7 (0.6–4.9)	1.5 (0.6–3.9)
Lymphtotoxin 60 (6, 11)	356	All	Whites	All	1.5 (1.01–2.18)	1.2 (0.9–1.6)†	All	1.3 (0.6–2.7)	0.8 (0.5–1.3)
	118	All	Whites	HP	1.8 (1.02–3.23)	1.3 (0.9–2.1)†	HP	0.9 (0.3–1.4)	0.6 (0.3–1.2)
	110	All	Whites	QP	1.9 (1.01–3.3)	1.5 (0.9–2.4)†	QP	1.5 (0.5–4.4)	1.0 (0.5–2.1)
	96	<32	Whites, Hispanics	All	0.4 (0.1–1.2)†	1.4 (0.8–2.6)†	DP	1.6 (0.5–4.8)	0.9 (0.4–2.0)
eNOS -922 (6, 11)	96	<32	Whites, Hispanics	All	0.5 (0.1–1.6)†	2.2 (1.2–4.0)†	All	1.4 (0.7–2.9)	0.9 (0.6–1.5)
	126	All	Whites	DP	0.5 (0.3–0.95)	0.7 (0.5–1.1)†	DP	1.7 (0.6–5.0)	0.7 (0.3–1.6)
iNOS -231 (6)	180	≥ 37	Whites	All	0.9 (0.5–1.7)†	1.6 (1.1–2.2)	All	1.01 (0.3–3.7)	1.9 (1.2–3.1)
EPCR 219 (6)	190	≥ 37	Whites	All	0 (0–2.3)†	1.6 (1.1–2.3)	All	1.2 (0.2–8.5)	0.9 (0.5–1.6)
	127	All	Whites	DP	0.9 (0.02–6.4)†	1.9 (1.2 – 3.1)	DP	2.4 (0.2–27.1)	0.8 (0.3–2.2)
MBL 54 (8)	49	All	Whites	DP	0.7 (0.1–3.2)	1.6 (1.1–2.4)	All	2.8 (0.5–15.0)	0.7 (0.4–1.3)
	21	≥ 37	Whites	DP	1.2 (0.03–8.1)	2.2 (1.1–4.2)	DP	2.2 (0.2–25.3)	0.6 (0.2–1.5)
MBL 52 (8)	65	≥ 37	Whites	QP	0 (0–18.8)	3.8 (1.03–11.1)	All	1.2 (0.1–18.9)	0.9 (0.4–1.7)
Thrombotic
FVL (506)	1	NA	NA‡	HP	NA	NA	All	-	0.8 (0.4–1.8)
MTHFR 677 (10)	58	32–36	Whites	All	2.6 (1.1–5.7)	1.9 (1.01–3.7)	All	0.4 (0.2–0.9)	0.6 (0.4–1.04)
	58	< 32	Whites	DP	2.8 (1.2–6.1)	1.6 (1.02–2.5)	DP	0.5 (0.1–2.0)	0.8 (0.4–1.7)
MTHFR 1298 (10)	20	32–36	Whites	DP	0.5 (0.1–2.3)	0.2 (0.02–0.07)	All	0.6 (0.7–3.8)	0.3 (0.8–2.0)
Prothrombin 20210 (10)	20	32–36	Whites	DP	0 (0.0–67.5)	4.3 (0.8–16.6)†§	All	-	0.5 (0.1–2.1)
PAI-1 11053 (6)	150	All	White Girls	All	1.9 (1.1–3.4)	1.6 (0.9–2.6)†	All	1.0 (0.5–2.0)	1.2 (0.7–2.1)
Apolipoprotein E
ε4 allele (15, 16)	209	All	White, Hispanic, black	All	2.9 (0.5–30.8)†	3.4 (1.4–8.7)	All	1.6 (0.5–5.6)	1.7 (1.01–2.9)
	40	All	Brazilian	All	Unknown	5.8 (1.3–34.8)†	HP	2.1 (0.5–9.1)	1.9 (0.96–3.8)
ε2 allele (16–18)	209	All	White, Hispanic, black	All	Unknown	12.0 (1.6–247)	All	-	1.1 (0.6–2.1)
	106	<32	Whites	All	Unknown	3.5 (1.1–12.7)	HP	-	1.3 (0.6–3.1)
	243	All	Brazilian	All	Unknown	2.8 (1.01–7.66)	DP	-	1.2 (0.4–3.6)

^*Note that none of the genetic associations were statistically significant after adjusting for multiple comparisons. Due to space constraints, this table does not include dominant genetic analyses (i.e. rare homozygote or heterozygote, compared to common homozygote). We found no significant associations when data were analyzed with dominant genetic comparisons.

^**DP = diplegic, HP = hemiplegic, QP = quadriplegic, All = DP + HP + QP. Note that when a polymorphism was not associated with overall CP, there was similarly no association found between that polymorphism and any subtype of CP.

^†These OR's were calculated from the raw data provided in published papers.

^‡NA = not available. An association between FVL and CP has only been reported in case reports and case series, and therefore no risk ratios are available.

^§The controls used in this calculation were term infants ≥ 37 weeks gestation.