Table 2.

Published examples of examples of experimentally validated functions for the microRNAs associated with the HPAI infections

microRNA ID	Loci			Known function	Reference
	Mouse	Macaque	Human
let-7f	13	15	9	Inhibiting IL-6 inflamation	Ibopoulos, cell 2009
miR-1	2	10	18	Inhibiting HDAC4 muscle proliferation	Chen, Nat Genetics 2006
miR-101	4	1	1	Inhibiting MPK in innate immune responce	Zhu, J Immunology 2010
miR-10a	11	16	17	miR-10 knock-downleads to NF-κF activation	Fang, PNAS 2010
miR-145	18	6	5	targeting STAT1 in cokin cancer cells	Gregerson, Plos one 2010
miR-151-5p	15	5	5	targeting RhoGDIA in tumor cell migration	Ding, Nature Cell Biology 2010
miR-188	X	X	X	unknown
miR-208a	14	7	14	involved in regulating acute inflammation	Recchiufi. FASEB J 2010
miR-21	11	16	17	Targets i-12p35 in allergic airway inflammation	Lu. J Immunology 2009
miR-223	X	X	X	Modulate NF-κB pathway through targeting Iκk-α	Li. Nature Immunology 2010
miR-23a	8	19	19	Involved in cell growth	Cherg, Nucleic Acids Res 2005
miR-23b	13	15	9	Involved in cell growth
miR-29a	6	3	7	Activates p53 by targeting CDC42 and p85α	Park, Nat Struct Mol Biol 2009
miR-29c	1	1	1	Activates p53 by targeting CDC42 and p85α	Park, Nat Struct Mol Biol 2010
miR-30b	15	8	8	Involved in NF-κb Meadiated immune responce	Zhou, Plos Pathogen 2009
miR-30c	4	1	1	Involved in NF-κb Meadiated immune responce	Zhou, Plos Pathogen 2009
miR-30d	15	8	8	Involved in NF-κb Meadiated immune responce	Zhou, Plos Pathogen 2009
miR-335	6	3	7	Targets Rb1 in p-53 meadiated stress responce	Scarola, Cancer Research 2010
miR-34c	9	14	11	Targets Myc in responce to DNA	Cannel, PNAS 2010
miR-429	4	1	1	Involved in stem cell differentiation	Lin, EMBO J 2009
miR-494	12	7	14	unknown
miR-98	X	X	X	Targeting CIS, an NF-κB activator	Hu, J Immunology, 2009
miR-99b	17	19	19	unknown