Table 1.
Maternal and offspring outcomes as a function of Treatment Group (mean±SE)
| Treatment group |
||||
|---|---|---|---|---|
| CON | PFC | ALC | P value | |
| Litters (#) | 28 | 24 | 21 | |
| Maternal weight gains GD6 to GD21 (g) | 120±5 | 70±4a | 73±4a | 0.000 |
| Maternal food consumptions GD6 to GD21 (g) | 377±5 | 229±1a | 226±8a | 0.000 |
| Gestation length (day) | 21.9±0.1 | 22.0±0.0 | 22.0±0.0 | NS |
| Uterine implantation sites (#/dam) | 16.3±0.5 | 16.5±0.5 | 15.1±0.6 | NS |
| Embryo resorptions (#/dam) | 1.9±0.5 | 1.3±0.3 | 1.5±0.4 | NS |
| Litter sizes (# pups/litter) | 14.4±0.6 | 15.2±0.6 | 13.6±0.7 | NS |
| Live births (# pups/litter) | 14.4±0.7 | 15.1±0.6 | 13.5±0.7 | NS |
| Pup birth weights (g) | 6.3±0.1 | 5.9±0.1a | 6.0±0.1a | 0.002 |
| Eye opening (day) | 14.1±0.1 | 14.1±0.1 | 14.4±0.1 | NS |
| Postnatal deaths (%) | 0.04 | 1.25 | 5.42b | 0.000 |
| Male PND28 weight (g) | 94.8±1.4 | 93.2±1.8 | 87.3±3.1c | 0.032 |
| Female PND28 weight (g) | 87.7±1.3 | 86.0±1.5 | 79.8±2.0c | 0.002 |
| Life span (day)d | 640±15 | 606±24 | 647±17 | NS |
NS=not significant, GD=gestation day, PND=postnatal day
a
ALC and PFC < CON
b
ALC > CON and PFC
c
ALC < CON
d
Animal numbers for Life span determination were CON=30, PFC=32 and ALC=31