Table 1.
Presence or Absence of Typical Eukaryotic Selenoproteins in Schistosoma mansoni
| Selenoprotein | Present in S. mansoni | Accession No. | Sec in S. mansoni | Sec location in protein (length of protein) | Identity / similarity to human orthologue (%) | SECISa |
|---|---|---|---|---|---|---|
| 15 kDa | YES | TC37305b | YES | 80 (149) | 36 / 59 | YES |
| DI | NO | -- | -- | -- | -- | -- |
| glutathione | ||||||
| peroxidase 1 | YES | XP_002577160 | YES | 43 (169) | 52 / 67 | YES |
| glutathione | ||||||
| peroxidase 2 | YES | XP_002571873 | YES | 62 (179) | 47 / 63 | YES |
| H | NO | -- | -- | -- | -- | -- |
| I | YES | CAX73136d | NO | -- | 39 / 59 | -- |
| J | NO | -- | -- | -- | -- | -- |
| K | NO | -- | -- | -- | -- | -- |
| M | NO | -- | -- | -- | -- | -- |
| N | NO | -- | -- | -- | -- | -- |
| O | YES | AAW26859e | NO | -- | 46 / 61 | -- |
| P | NO | -- | -- | -- | -- | -- |
| R | NOc | -- | -- | -- | -- | -- |
| S | YES | XP_002569582 | YES | 126 (127) | 30 / 42 | ?f |
| SPS2 | YES | XP_002580459 | YES | 35 (392) | 48 / 65 | YES |
| T | YES | XP_002581129 | YES | 56 (204) | 45 / 63 | YES |
| TGR | YES | AAK85233 | YES | 597 (598) | 54 / 71 | YES |
| U | YES | XP_002574167 | NO | -- | 42 / 62 | -- |
| V | NO | -- | -- | -- | -- | -- |
| W | YES | TC38149b | YES | 13 (84) | 61 / 80 | YES |
Selenocysteine insertion sequences (SECIS) identified using SECISearch 2.19 [20] at http://genome.unl.edu/SECISearch.html.
TC37305 and TC38149 are tentative consensus sequences generated from expressed sequence tags of S. mansoni. The sequences are available at http://compbio.dfci.harvard.edu/tgi/cgibin/tgi/gimain.pl?gudb=s_mansoni
SelR is a form of methionine-R-sulfoxide reductase (MsrB). S. mansoni has two MsrB proteins (MsrB2a - AAT77263 and MsrB2b - AAT77264) neither of which contains Sec [110].
S. japonicum GenBank accession for Sel I; the S. mansoni Sel I is incorrectly annotated.
Partial S. japonicum GenBank accession for an ortholog for Sel O. The S. mansoni Sel O is incorrectly annotated.
Although predicted to be a selenoprotein, no SECIS element was identified by SECISearch.