Table 2.

Multivariate Regression Adjusted Associations of 1 SD (389 cm/s) Higher Baseline aPWV With Lower Year 3 Cognitive Scores

Cognitive Measure (SD)	Model 1, aPWV β (95% CI)		Model 2, aPWV β (95% CI)		Model 3, aPWV β (95% CI)
	Cognitive Measure, SDs*	Cognitive Measure, Original Units†	Cognitive Measure, SDs*	Cognitive Measure, Original Units†	Cognitive Measure, SDs*	Cognitive Measure, Original Units†
Global function (4.9)	−0.17 (−0.25, −0.09)	−0.82 (−1.24, −0.40)	−0.11 (−0.19, −0.03)	−0.53 (−0.89, −0.17)	−0.11 (−0.19, −0.03)	−0.55 (−0.91, −0.19)
Verbal memory (3.0)	−0.09 (−0.17, −0.01)	−0.26 (−0.52, 0.00)	−0.06 (−0.14, 0.02)	−0.17 (−0.41, 0.07)	−0.07 (−0.15, 0.01)	−0.20 (−0.44, 0.04)
Psychomotor speed (18.6)	−0.18 (−0.26, −0.10)	−3.40 (−4.96, −1.84)	−0.11 (−0.19, −0.03)	−2.13 (−3.53, −0.73)	−0.09 (−0.17, −0.01)	−1.59 (−3.03, −0.15)
Perceptual speed (5.0)	−0.18 (−0.26, −0.10)	−0.90 (−1.32, −0.48)	−0.12 (−0.20, −0.04)	−0.61 (−0.97, −0.25)	−0.12 (−0.20, −0.04)	−0.60 (−0.98, −0.22)

Notes: Model 1 unadjusted. Model 2 adjusted for age, sex, race, education, and clinic site. Model 3 additionally adjusted for body mass index, mean arterial pressure, cholesterol, heart rate, smoking status, physical activity, depressive symptoms, prevalent hypertension, coronary heart disease, cerebrovascular disease, and diabetes mellitus. CI = confidence interval.

^*Beta = Δ SDs of cognitive measure per SD of aPWV.

^†Beta= Δ cognitive measure (original units) per SD of aPWV.