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. 2011 Aug 26;66A(12):1286–1299. doi: 10.1093/gerona/glr125

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© The Author 2011. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

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Figure 11. — The survival curves of Tg(TRX1)^+/0 and wild-type (WT) mice. Survival curves of Tg(TRX1)^+/0 and WT mice from two cohorts are presented. The first cohort consists of 48 male WT and 41 male Tg(TRX1)^+/0 mice (Graph A: left), and the second cohort consists 60 male WT and 60 male Tg(TRX1)^+/0 mice (Graph B: middle) and 40 female WT and 40 female Tg(TRX1)^+/0 mice (Graph C: right). The survival curves were compared statistically using the log-rank test. The survival curves were not significantly different between Tg(TRX1)^+/0 and WT mice. The male Tg(TRX1)^+/0 mice showed significant increases in 90% survival (both cohorts), and only the first male cohort showed a significant increase in 75% survival compared with WT mice. However, we found no difference in the median, 25%, and 10% survival between Tg(TRX1)^+/0 and WT mice in two male cohorts. In females, although the Tg(TRX1)^+/0 mice seemed to extend life span in the earlier part of life compared with WT mice, none of the survivals parameters were statistically significant.