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. 2011 Aug 22;66A(12):1309–1317. doi: 10.1093/gerona/glr146

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© The Author 2011. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

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Figure 4. — Cytokine release (tumor necrosis factor-α [TNF-α] and interleukin [IL-6]) following lipopolysaccharide (LPS) stimulation of peripheral blood mononuclear cells (PBMC) from adult baboons. PBMC from baboons had an age-related increase in TNF-α and IL-6 release after phosphate-buffered saline (PBS; A and C) or LPS treatment (B and D). There was a greater mean cytokine release following PBS treatment (E and G) in adult (5–19 years of age) and aged baboons (≥20 years of age) compared with young baboons (<5 years of age). After LPS treatment, TNF-α release (F) was greater in adult and aged baboons but IL-6 release did not differ from that observed in young baboons (H). There was no difference between adult and aged baboons. (A) TNF-α after PBS: r = .6, p < .0001; (B) TNF-α after LPS: r = .4, p < .01; (C) IL-6 after PBS: r = .6, p < .0001; (D) IL-6 after LPS: r = .3, p < .05; (E–G) *denotes difference from young group; *p < .05, **p < .01, ***p < .001.