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. 2011 Aug 22;66A(12):1309–1317. doi: 10.1093/gerona/glr146

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© The Author 2011. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

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Figure 6. — Effect of serum anti-inflammatory hormone and cytokine concentration on cytokine response to lipopolysaccharide (LPS) stimulation of whole blood. (A–D) Serum DHEA-S (A: r = −.4, p < .01) and cortisol (B: r = −.27, p = .07) decreased with age; transforming growth factor (TGF)-β; D: r = .6, p < .0001) increased with age; interleukin (IL)-10 was not correlated with age (C: r = .26, p = .08). (E–L) IL-6 release following LPS stimulation was negatively correlated with DHEA-S concentration (I: r = −.5, p < .01) and cortisol (J: r = −.35, p < .05) and positively correlated with TGF-β (H: r = .4, p < .01). TNF-α release following LPS stimulation was negatively correlated only with DHEA-S concentration (E: r = −.3, p < .05).