Figure 3. Baseline expression of TNFR2 predicts tolerance to LPS irrespective of genotype.
Scatter plots of tolerance assayed at the level of TNF protein secretion showing correlation with TNFR2 mRNA expression (r2 0.36, P <0.0001) (A) ,and with TNFR1 mRNA expression (r2 <0.01, P ns) (B). Correlation of secondary TNF protein with TNFR2 mRNA expression (r2 0.88, P <0.0001) (C), sTNFR2 protein (r2 0.18, P <0.0001) (D), and TNFR1 mRNA expression (r2 0.02, P ns) (E). All transcript abundance expressed relative to ACTB.