Table 2.

Characteristics of included studies.

Trial	Design	Patients	Age (mean)	%male	Tx Duration (mos)	Jadad Score	Jadad Problems
Agnelli et al. [6]	RCT	90	—	—	12	6	Not double blind
		91	—	—	3
Agnelli et al. [7]	RCT	134	67	55	12	6	Not double blind
		133	68	61	3
Farraj [20]	RCT	32	41	62	24	4	Not double blind Withdrawals/dropouts No statistics methods
		32	42	56	6
Legnani et al. [24]	Cohort	628	67	53	7	4	Not randomized
Kyrle et al. [22]	Cohort	453	45	0	9	4	Not randomized
		373	51	100	8
Palareti et al. [19]	RCT	385	59	55	13.0	6	Not double blind
		120	68	42	10.8
Palareti et al. [25]	Cohort	282	70	55	7.5	4	Not randomized
Schulman et al. [21]	RCT	289	63	63	6	6	Not double blind
Poli et al. [23]	Cohort	183	60	57	14.9	3	Not randomized