Table 3.
Genotype results in a sample of patients with virological failure to first-line ART in Cape Town, South Africa (n=110). Mutations noted in the IAS-USA listing which were not noted in this group are not listed here.
| NRTI mutations | |||
|---|---|---|---|
| Ref | Loci | AA | n(%) |
| M | 41 | ML | 1 (0.9) |
| K | 65 | R | 10 (9.0) |
| D | 67 | N | 14 (13) |
| T | 69 | DN | 2 (1.8) |
| K | 70 | KR | 4 (3.6) |
| L | 74 | L/I/V | 1 (0.9) |
| V | 75 | IM | 3 (2.7) |
| V | 118 | I | 2 (2.7) |
| M | 184 | V | 86 (78) |
| T | 215 | FSY | 9 (8.1) |
| K | 219 | EQ | 5 (4.5) |
| K | 238 | T | 2 (1.8) |
| Wild type n(%) | 7 (6.4) | ||
| NNRTI mutations | |||
|---|---|---|---|
| Ref | Loci | AA | n(%) |
| A | 98 | G | 4 (3.6) |
| L | 100 | I | 2 (1.8) |
| K | 101 | EP | 18 (16) |
| K | 103 | N | 60 (55) |
| V | 106 | M | 34 (31) |
| V | 108 | IV | 13 (12) |
| E | 138 | A | 2 (1.8) |
| V | 179 | DV | 6 (5.5) |
| Y | 181 | CY | 11 (10) |
| Y | 188 | HL | 9 (8.1) |
| G | 190 | ACE | 22 (20) |
| P | 225 | H | 15 (14) |
| F | 227 | L | 7 (6.4) |
| M | 230 | L | 8 (7.3) |
| PI mutations | |||
|---|---|---|---|
| Ref | Loci | AA | n(%) |
| L | 10 | IVF | 7 (6.4) |
| I | 13 | V | 8 (7.3) |
| G | 16 | E | 9 (8.1) |
| K | 20 | RT | 30 (27) |
| D | 30 | N | 1 (0.9) |
| L | 33 | FV | 2 (1.8) |
| M | 36 | I | 95 (86) |
| L | 63 | HLPSTV | 66 (60) |
| H | 69 | K | 103 (94) |
| G | 73 | S | 1 (0.9) |
| T | 74 | S | 14 (13) |
| V | 77 | I | 17 (15) |
| LV | 82 | AF | 1 (0.9) |
| L | 89 | IM | 90 (82) |
[Text in bold indicates thymidine analogue mutations (TAMs).]