Table I.
Patient characteristics at baseline.
| Characteristic | Total (n = 1002) | No progression (n = 734) | Progression (n = 268) | p-Value |
|---|---|---|---|---|
| Age at diagnosis, n (%) | ||||
| <55 | 333 (33) | 258 (35) | 75 (28) | 0.10 |
| 55-65 | 313 (31) | 222 (30) | 91 (34) | |
| >65 | 356 (36) | 254 (35) | 102 (38) | |
| Mean age | 60.1 | 59.6 | 61.3 | |
| Median age (range) | 61 (21-91) | 60 (21-91) | 61 (27-90) | 0.10 |
| Gender, n (%) | ||||
| Female | 565 (56) | 430 (59) | 135 (50) | 0.02 |
| Male | 437 (44) | 304 (41) | 133 (50) | |
| Stage, n (%) | ||||
| I | 187 (20) | 147 (21) | 40 (16) | 0.06 |
| II | 198 (21) | 150 (22) | 48 (19) | |
| III | 234 (25) | 170 (25) | 64 (25) | |
| IV | 327 (35) | 223 (32) | 104(41) | |
| Missing | 56 | 44 | 12 | |
| B-symptoms, n (%) | ||||
| No | 812 (85) | 601 (87) | 211 (82) | 0.11 |
| Yes | 138 (15) | 93 (13) | 45 (18) | |
| Missing | 52 | 40 | 12 | |
| HGB < 12*, n (%) | ||||
| No | 668 (81) | 502 (85) | 166 (73) | < 0.0001 |
| Yes | 152 (19) | 90(15) | 62 (27) | |
| Missing | 182 | 142 | 40 | |
| Elevated LDH*, n (%) | ||||
| No | 477 (86) | 353 (89) | 124 (80) | 0.01 |
| Yes | 76 (14) | 45(11) | 31 (20) | |
| Missing | 449 | 336 | 113 | |
| 4 + positive nodes, n (%) | ||||
| No | 543 (67) | 412 (70) | 131 (58) | 0.0008 |
| Yes | 272 (33) | 176 (30) | 96 (42) | |
| Missing | 187 | 146 | 41 | |
| ECOG PS*, n (%) | ||||
| 0 | 581 (68) | 445 (71) | 136 (60) | 0.0005 |
| 1 | 209 (25) | 145 (23) | 64 (28) | |
| 2 + | 60(7) | 33(5) | 27(12) | |
| Missing | 152 | 111 | 41 | |
| Payer type | ||||
| Private | 438 (44) | 330 (45) | 108 (40) | 0.06* |
| Medicare | 537 (53) | 381 (52) | 156 (58) | |
| Medicaid | 9(1) | 6(1) | 3(1) | |
| Other | 18(2) | 17(2) | 1(0) | |
| Follow-up time, n (%) | ||||
| < 12 months | 56(6) | 28(4) | 30(11) | |
| ≥ 12 months | 938 (94) | 700 (96) | 236 (89) | |
| Mean follow-up time, months | 35.1 | 37.0 | 29.8 | |
| Median follow-up, months (range) | 37(1-53) | 39 (3-53) | 32(1-53) | |
| Alive at end of follow-up, n (%) | 983 (99) | 725 (99.6) | 258 (97) | |
HGB, hemoglobin; LDH, lactate dehydrogenase; ECOG PS, Eastern Cooperative Oncology Group Performance Status.
*
Based on entry in iKnowMed closest to index date (±14 days).