FIGURE 1.

Actions of neuropeptide Y (NPY) and a Y₂ antagonist in rat hippocampal slices. A: effect of npy on the population excitatory postsynaptic potential (pEPSP) evoked by electrical stimulation of stratum radiatum in area CA2, recorded extracellularly in area CA1. Black trace, control response; red trace, response in the presence of 1 mM NPY; blue trace, response to NPY in the presence of the Y₂-receptor antagonist, BIIE 0246 (100 NM). B: effect of NPY on primary afterdischarges (18 ADs) in the stimulus train–induced bursting (STIB) model in rat hippocampal slice. extracellular recording from area CA3 shows tonic–clonic 18 AD in control (left trace) in the presence of NPY (300 nm) (center trace), and in 300 nm NPY after pretreatment with BIIE 0246 (100 NM). C: time course of the inhibition of the 18 AD by NPY (300 nm) in the absence (red circles) and presence (blue triangles) of BIIE 0246 (100 nm). (B and C modified from ref. 53, with permission).