Table 3.
Results from Cox Proportional Hazards Model with Time Dependent Covariates on Indianapolis and Ibadan Subjects
| Variable | Indianapolis
|
Ibadan
|
||
|---|---|---|---|---|
| Hazard Ratio (95% Confidence Interval) | p-value | Hazard Ratio (95% Confidence Interval) | p-value | |
| Age < 75 | ||||
| Number of ApoE ε4 alleles | 2.00 (1.19–3.35) | 0.0089 | 1.04 (0.78–1.40) | 0.7782 |
| Age at baseline | 1.08 (0.96–1.22) | 0.2124 | 1.16 (1.09–1.24) | < 0.0001 |
| Smoking history | 0.98 (0.45–2.13) | 0.9499 | 1.23 (0.76–2.01) | 0.3987 |
| Education* | 0.97 (0.87–1.07) | 0.4898 | 1.04 (0.63–1.73) | 0.8842 |
| Hypertension | 2.49 (1.02–6.04) | 0.0442 | 0.60 (0.37–0.95) | 0.0312 |
| Male | 2.42 (1.15–5.07) | 0.0198 | 1.17 (0.75–1.82) | 0.5023 |
| Cancer | 1.69 (0.73–3.91) | 0.2227 | NA | NA |
| Diabetes | 1.67 (0.88–3.18) | 0.1180 | 1.27 (0.57–2.82) | 0.5571 |
| Heart disease | 0.83 (0.44–1.58) | 0.5754 | 1.38 (0.95–2.01) | 0.0950 |
| Stroke | 1.59 (0.79–3.19) | 0.1983 | 3.06 (1.49–6.25) | 0.0022 |
| Dementia | 1.88 (0.74–4.79) | 0.1884 | 4.28 (2.39–7.65) | < 0.0001 |
| Age 75+ | ||||
| Number of ApoE ε4 alleles | 0.71 (0.45–1.10) | 0.1238 | 1.21 (0.83–1.75) | 0.3274 |
| Age at baseline | 1.06 (1.01–1.12) | 0.0180 | 1.03 (1.00–1.07) | 0.0514 |
| Smoking history | 1.05 (0.63–1.77) | 0.8528 | 1.15 (0.70–1.89) | 0.5721 |
| Education * | 0.94 (0.88–1.01) | 0.0971 | 0.91 (0.49–1.67) | 0.7590 |
| Hypertension | 1.25 (0.73–2.15) | 0.4183 | 0.96 (0.51–1.81) | 0.9062 |
| Male | 2.33 (1.40–3.90) | 0.0012 | 1.48 (0.89–2.48) | 0.1320 |
| Cancer | 0.73 (0.38–1.41) | 0.3500 | NA | NA |
| Diabetes | 1.15 (0.67–1.96) | 0.6199 | 1.26 (0.44–3.60) | 0.6668 |
| Heart Disease | 1.41 (0.83–2.37) | 0.2010 | 1.18 (0.68–2.04) | 0.5510 |
| Stroke | 1.56 (0.82–2.96) | 0.1737 | 1.69 (0.63–4.54) | 0.3018 |
| Dementia | 2.34 (1.26–4.34) | 0.0069 | 3.56 (1.88–6.74) | < 0.0001 |
*
Mean years of education (SD) for Indianapolis; Number of subjects (%) with any schooling for Ibadan.