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. Author manuscript; available in PMC: 2012 Jan 1.
Published in final edited form as: Drug Discov Today Dis Models. 2011 Winter;8(4):129–137. doi: 10.1016/j.ddmod.2011.07.002

Figure 5. Relative regional glucose metabolic activity during NREM sleep in primary insomnia and good sleeper subjects.

Figure 5

18F-fluoro-deoxyglucose was injected in 18 primary insomnia and 18 good sleeper subjects after they had been in NREM sleep for 10 minutes. Following 20 minutes of glucose uptake, subjects were awakened for 3-D PET scans. The amount of NREM sleep during the uptake period did not differ between the two groups. Using SPM-2, regions with greater relative glucose during the uptake period in insomnia patients were identified. The pseudo-color map shows a map of voxel-by-voxel t-values. Insomnia patients had greater relative glucose metabolism in broad regions of the dorsolateral and parietal cortex and the precuneus.